Use Caution/Monitor. Concerta is long-acting Ritalin (methylphenidate). Contraindicated (1)diethylpropion increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)methylphenidate will decrease the level or effect of verapamil by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. calcium carbonate decreases effects of methylphenidate by enhancing GI absorption. arformoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Currently on methylphenidate 5 mg BID or . Mechanism: unknown. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor BP. Risk of acute hypertensive episode. By clicking send, you acknowledge that you have permission to email the recipient with this information. Monitor BP. Use Caution/Monitor. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. Modify Therapy/Monitor Closely. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. salmeterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. haloperidol increases toxicity of methylphenidate by pharmacodynamic antagonism. Contraindicated. pramipexole, methylphenidate. Contraindicated. Risk of acute hypertensive episode. Use Caution/Monitor. sufentanil SL, methylphenidate. Contraindicated. Use Caution/Monitor. Risk of acute hypertensive episode. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Use Caution/Monitor. Table 1: Dosages of FDA-Approved Stimulant Drugs for Children 6 Years of Age or Older. Applies only to oral form of both agents. Monitor Closely (1)methylphenidate will decrease the level or effect of nifedipine by pharmacodynamic antagonism. Contraindicated. Comment: Potential for additive CNS effects.lurasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Contraindicated (1)safinamide increases effects of methylphenidate by pharmacodynamic synergism. only. Methylphenidate may diminish antihypertensive effects. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. Monitor BP. Caffeine should be avoided or used cautiously. . Modify Therapy/Monitor Closely. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Individual plans may vary Monitor BP. Use Caution/Monitor. pirbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. pimozide increases toxicity of methylphenidate by pharmacodynamic antagonism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Methylphenidate may diminish antihypertensive effects. levodopa, methylphenidate. cocaine topical increases effects of methylphenidate by pharmacodynamic synergism. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Other (see comment). Contraindicated (1)isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. Comment: Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. methylphenidate will decrease the level or effect of lisinopril by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Modify Therapy/Monitor Closely. Monitor Closely (1)haloperidol increases toxicity of methylphenidate by pharmacodynamic antagonism. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Other (see comment). Contraindicated. rasagiline increases effects of methylphenidate by pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor. Compared to Concerta, the newer. Minor/Significance Unknown. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Interaction specifically associated with Ritalin LA. Use Caution/Monitor. Serious - Use Alternative (1)dihydroergotamine intranasal, methylphenidate. Monitor BP. Monitor Closely (1)methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. This means that you only need to take. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor Closely (1)methylphenidate will decrease the level or effect of nicardipine by pharmacodynamic antagonism. Other (see comment). This drug is available at the lowest co-pay. Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; may gradually increase dose at weekly intervals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate . The difference between Concerta and Ritalin is how long the. prochlorperazine, methylphenidate. Use Caution/Monitor. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Use Caution/Monitor. Use Caution/Monitor. ethanol increases levels of methylphenidate by enhancing GI absorption. Methylphenidate may diminish antihypertensive effects. Potential for additive CNS stimulation. Either increases effects of the other by pharmacodynamic synergism. Monitor BP. Avoid or Use Alternate Drug. Monitor Closely (1)pimavanserin increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. clozapine increases toxicity of methylphenidate by pharmacodynamic antagonism. desipramine, methylphenidate. Use Caution/Monitor. Contraindicated. Methylphenidate may diminish antihypertensive effects. methylphenidate will decrease the level or effect of nisoldipine by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will decrease the level or effect of fosinopril by pharmacodynamic antagonism. Monitor Closely (2)famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Use Caution/Monitor. Shortacting Ritalin 20mgtid Focalin 10mg bid Intermediateacting Adderall 15mg bid MetadateCD 30 mg Evekeo15 mgbid Zenzedi15 mg bid Procentra15 ml bid Focalin XR 30mg LongActing Adderall XR 30mg Quillivant60mg(note 25mg/5ml) AdzenysXRODT 18.8mg Quillichew60 mg AptensioXR 60mg(actuallyequivto ritalin 25.9 twice a day) methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. Monitor Closely (1)esomeprazole decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (1)cimetidine decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (1)methylphenidate will decrease the level or effect of nisoldipine by pharmacodynamic antagonism. Other (see comment). Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. green tea, methylphenidate. Avoid or Use Alternate Drug. Monitor BP. Use Caution/Monitor. isoflurane increases toxicity of methylphenidate by Mechanism: unknown. Use Caution/Monitor. This drug is available at a higher level co-pay. Monitor BP. Minor/Significance Unknown. Methylphenidate may diminish antihypertensive effects. Either increases effects of the other by serotonin levels. Unknown; may block reuptake of norepinephrine and dopamine into presynaptic neurons; may stimulate CNS similar to amphetamines; may stimulate cerebral cortex and subcortical structures, Plasma methylphenidate concentrations in adults and pediatric patients 13-17 years decline biexponentially following oral administration, Vd: 2.65 L/kg (d-methylphenidate); 1.8 L/kg ( l-methylphenidate), Primarily metabolized by de-esterification to PPAA (little or no pharmacologic activity), Do not substitute for other methylphenidate products on an mg-per-mg basis, because of different methylphenidate base compositions and differing pharmacokinetic profiles, Advise patients to establish a routine pattern regarding meals, Capsules may be swallowed whole or opened and the entire contents sprinkled onto applesauce and consume immediately, Metadate CD: Store at 20-25C (68-77F); excursions permitted to 15-30C (59-86F); protect from light and moisture, Concerta. Applies only to oral form of both agents. Contraindicated. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. Monitor Closely (1)chlorpromazine, methylphenidate. Contact the applicable plan Contraindicated. However, the dose is usually not more than 60 mg per day. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. ether increases toxicity of methylphenidate by Mechanism: unknown. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Minor/Significance Unknown. Monitor BP. Monitor BP. Monitor BP. Use Caution/Monitor. Monitor BP. Concerta and Ritalin share the same active ingredient. Monitor BP. Applies only to oral form of both agents. Methylphenidate may diminish antihypertensive effects. Applies only to oral form of both agents. Mechanism: pharmacodynamic synergism. Monitor Closely (1)epinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Monitor Closely (1)loxapine inhaled increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)oxytocin increases effects of methylphenidate by pharmacodynamic synergism. Potential for additive CNS stimulation. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. Monitor Closely (1)methylphenidate and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use Caution/Monitor. Concerta is a long-acting drug: It increases dopamine steadily. Monitor BP. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Adhansia XR: 25 mg PO qAM initially; may titrate upward in increments of 10-15 mg at intervals of at least 5 days; dosages >85 mg/day associated with increased incidence of certain adverse reactions, Aptensio XR: 10 mg PO qDay in AM; may increase weekly by 10-mg increments; not to exceed 60 mg/day, Concerta: Initial for methylphenidate-nave, 18-36 mg PO qDay; may increase by 18-mg increments at weekly intervals; maintenance dose is 18-72 mg/day, Metadate CD: Initial, 20 mg PO qAM before breakfast; may increase in 10- to 20-mg increments; not to exceed 60 mg/day, Methylin ER: Duration of action ~8 hr; may use in place of methylphenidate IR tablets when 8-hr dosage of methylphenidate ER corresponds to titrated 8-hr dosage of methylphenidate IR; not to exceed 60 mg/day, Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; may gradually increase dose at weekly intervals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate, QuilliChew ER (chewable extended-release tablets): 20 mg PO qAM initially; may titrate up or down weekly in increments of 10 mg, 15 mg, or 20 mg; not to exceed 60 mg/day, Jornay PM: Initial, 20 mg PO qDay in the evening; may titrate weekly in increments of 20 mg; not to exceed 100 mg/day; initiate dosing at 8:00 pm; adjust timing of administration between 6:30 pm and 9:30 pm to optimize tolerability and efficacy the next morning and throughout the day, Relexxii: Initial for methylphenidate-nave, 18-36 mg PO qDay; may increase by 18-mg increments at weekly intervals; maintenance dose is 18-72 mg/day; not to exceed 72 mg/day, Ritalin LA: Initial, 20 mg PO qAM; may adjust dose in weekly 10-mg increments, not to exceed 60 mg/day (patients requiring a lower initial dose may begin with 10 mg), Methylin, Ritalin (immediate-release tablets and oral solution): 20-30 mg/day PO divided q8-12hr, 30-45 minutes before meals; some patients may require 40-60 mg/day; in others, 10-15 mg/day may be adequate, Methylin ER: Duration of action is approximately 8 hr; may use in place of methylphenidate IR tablets when 8-hr dosage of methylphenidate ER corresponds to the titrated 8-hr dosage of methylphenidate IR, <6 years: Safety and efficacy not established.